Importance of Ca2+ in gastric epithelial restitution—new views revealed by real-time in vivo measurements
E Aihara, MH Montrose - Current opinion in pharmacology, 2014 - Elsevier
Highlights•Two-photon microscopy allows unique opportunities for monitoring of gastric
events.•Two-photon damage model reveals functional microdomains of Ca 2+ mobilization.•
Intracellular Ca 2+ increases selectively on restituting gastric epithelial cells.•Gastric luminal
Ca 2+ accelerates gastric epithelial cell restitution.It has been a few decades since Ca 2+
was identified as one of the important factors that can accelerate gastric wound repair as
well as contribute to epithelial homeostasis and regulation of gastric secretions. The …
events.•Two-photon damage model reveals functional microdomains of Ca 2+ mobilization.•
Intracellular Ca 2+ increases selectively on restituting gastric epithelial cells.•Gastric luminal
Ca 2+ accelerates gastric epithelial cell restitution.It has been a few decades since Ca 2+
was identified as one of the important factors that can accelerate gastric wound repair as
well as contribute to epithelial homeostasis and regulation of gastric secretions. The …
